A prospective, population-based cohort study using Danish nationwide registers included all individuals born in Denmark before December 31, 2005, who were alive, aged at least 16 years, and living in Denmark between January 1, 1995, and December 31, 2021 (a total of 6, 651,765 individuals). "The findings suggest that cannabis use disorder is independently associated with bipolar disorder and unipolar depression." Importantly, there appears to be a need for improved knowledge on the dose-dependent effects of cannabis use on brain, cognition, and behavior; identification of risk factors for transition from cannabis use (disorder) to psychiatric disorders; and the effects of cannabis cessation on long-term psychiatric risk.
Author: Jefsen OH